Update: Psilocybe mushrooms cultivation and clinical trials

TAIRAWHITI, New Zealand - Rua Bioscience (NZX:RUA) is pleased to announce a number of exciting milestones in a health research collaboration focused on the production of indigenous mushrooms containing the psychoactive psilocybin. The company has been granted an expanded licence by Manatu Hauora, the NZ Ministry of Health, to now research all ten indigenous Psilocybe varieties. The cultivation program, led by Rua Bioscience and local experts, has sourced fungi, established cultivation facilities and sample testing is now being undertaken at the Institute of Environmental Science and Research (ESR). A new research agreement has been executed involving eight partners: Rangiwaho Marae, Institute of Environmental Science & Research (ESR), Manaaki Whenua Landcare Research, the Matai Medical Research Institute, Turanga Health, IO Limited, the New Zealand Drug Foundation and Rua Bioscience. Other partners are expected to participate in the collaboration as the research progresses. Phase I of the marae-based psilocybin clinical trial protocol received full approval from the Health & Disability Ethics Committees (HDEC), and the Medsafe Standing Committee On Therapeutic Trials (SCOTT) has granted conditional approval for the trial to proceed. The Tu Wairua collaboration brings together leading experts and organisations in a concerted effort to deepen understanding of indigenous varieties of Psilocybe fungi and explore their therapeutic potential. This collaboration aligns with Rua Bioscience's mission to harness the power of nature to improve health outcomes and promote well-being. Paul Naske, CEO of Rua Bioscience, said, "We are incredibly excited to embark on this journey with our esteemed partners. Through the Tu Wairua collaboration, we aim to investigate the potential of indigenous Psilocybe varieties to benefit individuals and communities alike. By combining local knowledge with scientific research, Tu Wairua can pave the way for innovative approaches to health and wellness with mana whenua leading the process." Jymal Morgan, General Manager Maori Impact at ESR, expressed his organisation's enthusiasm, stating, "ESR is proud to be part of the Tu Wairua collaboration, which aligns closely with our commitment to honouring and supporting Maori communities. ESR is bringing our expertise in analytical chemistry to Matauranga Maori to enable innovation." Jody Toroa, a trustee at Rangiwaho Marae said the marae whanau were pleased to be the conduit for such an innovative initiative bringing together matauranga Maori, health researchers and medicine manufacturing companies. "This is new ground for everyone involved, it's complex but so interesting for our whanau and we can't wait to see whether it might help those we know suffering from addictions and historical trauma." Rangiwaho Marae has facilitated access to kaupapa Maori trainers who will work along psychedelic therapy trainers to prepare a team of kaitieki or guides, to support participants in each phase of the clinical trial. Dr. Patrick McHugh, clinical lead at the Matai Medical Research Institute, highlighted the potential impact of the collaboration, stating, "Matai is thrilled to join forces with Rua Bioscience and other partners in the Tu Wairua collaboration. By combining our expertise in research and technology, we can unlock new insights into the therapeutic potential of indigenous Psilocybe varieties." ENDS The person who authorised this announcement: Paul Naske Chief Executive Officer Paul.naske@ruabio.com +64 21 445154 For media inquiries, please contact: Paul Naske - paul.naske@ruabio.com Manu Caddie - manu@enquire.co.nz About the participating organisations: o Rua Bioscience (NZX:RUA) is a leading Aotearoa New Zealand-based biotechnology company specialising in the research, development, and commercialisation of natural products and medicinal cannabis products for health and wellness. o Institute of Environmental Science and Research (ESR) is a Crown Research Institute dedicated to the health, wellbeing and safety of our communities. Using world-leading science, we monitor disease, test food and products, safeguard our water, support the justice sector and more. o Manaaki Whenua - Landcare Research is a Crown Research Institute that conducts science and research focused on environmental issues, opportunities and solutions for Aotearoa New Zealand. This research collaboration has drawn on their expertise in the identification and cataloguing of indigenous organisms. o NZ Drug Foundation works to prevent drug harm and build a healthier society. o The Matai Medical Research Institute focuses on brain research and technology development for human health and well-being. o Turanga Health is a leading iwi health provider based in Turanganui-a-Kiwa providing primary health care and wellbeing services. o IO Limited is a company focused on research and utilising taonga species in partnership with kaitiaki groups across Aotearoa New Zealand. End CA:00428146 For:RUA Type:MKTUPDTE Time:2024-03-18 13:02:42